• Manufacturing of Drugs and Active Pharmaceutical Ingredients (APIs)
    The Inversina Tumbler Mixer ensures a perfectly uniform blend of ingredients for a wide range of pharmaceutical drugs and APIs. For production scale units (20L and larger), complete cGMP documentation turnover packages are available. Furthermore, we offer site acceptance tests, installation, and operator training anywhere in the world.
  • Compounding & Compacting
    Compounding pharmacies, medical doctors, and hospitals use both manual and electric Inversinas in order to achieve reliable and reproducible formulation of custom and/or OTC drug products.
  • Formulation Development
    All our Inversinas use the same 3D Inversion Kinematics, known as the Paul Schatz Principle. This allows for easily replicated results and great scale-up properties from development to manufacturing.
  • Quality Assurance / Quality Control and Sample Preparation
    After a sample of the product is obtained, moving it to the laboratory for testing or even letting it sit for some time can lead to segregation. In some cases a number of samples need to be homogenized prior to further analysis. In such circumstances, Inversinas up to 20L ensure perfect mixtures of one or more samples at the same time, while allowing for the use of virtually any container, tube, or vial.
  • References:
    More than half of the top 20 pharmaceutical companies in the world (as per 2010 revenue reports) own one or more of our Inversinas!

    Drugs manufactured in the Inversina include both prescribed and OTC products. Therapeutic applications include diabetes care, pain relief, antibiotics, cardiovascular disease, drugs against infections, various kinds of vaccines, and many other uses for both human and animal health applications. Delivery methods include oral / solid dose drugs, lyophilized / freeze-dried products, as well as inhaled dry powders and sterile injectables.

    We invite you to visit our Testimonials section. Personal references are available upon request.

  • Publications:

Sublingual Diffusion of Epinephrine Microcrystals from Rapidly Disintegrating Tablets for the Potential First-Aid Treatment of Anaphylaxis: In Vitro and Ex Vivo Study Mutasem M. Rawas-Qalaji,corresponding author Shima Werdy, Ousama Rachid, F. Estelle R. Simons, and Keith J. Simons AAPS PharmSciTech. 2015 Oct; 16(5): 1203–1212

Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy Elisabeth Peeters, Ana Filipa Tavares da Silva, Maunu Toiviainen, Jeroen Van Renterghem, Jurgen Vercruysse, Mikko Juuti, Joao Almeida Lopes, Thomas De Beer, Chris Vervaet, Jean-Paul Remon Asian Journal of Pharmaceutical Sciences Volume 11, Issue 4, August 2016, Pages 547-558

Patent: Compositions for bone reconstruction Guy Daculsi, Thomas MIRAMOND, Chantal Gobin Current Assignee: Universite de Nantes Institut National de la Sante et de la Recherche Medicale (INSERM) BIOMATLANTE Volume 11, Issue 4, August 2016, Pages 547-558

Evaluation of the Inversina Manual Mixer – Powders and Liquids Compounding Pharmacy Whitepaper

Evaluation of the Inversina Manual Mixer – Powders and Liquids Compounding Pharmacy Whitepaper

Rate-Dependent Mechanical Properties of Granulated Pharmaceutical Powder Formulations Particulate Science and Technology: Volume 30, Issue 2, 2012

The use of single particle mechanical properties for predicting the compressibility of pharmaceutical materials Powder Technology – Volume 225, July 2012, Pages 43–51

Fabrication of inhalable spore like pharmaceutical particles for deep lung deposition Particulate Science and Technology: Volume 30, Issue 2, 2012

Sustained release properties of crosslinked and substituted starches Journal of Applied Polymer Science – Volume 117, Issue 3, pages 1558–1565, 1 August 2010

Relationships Between Tablet Physical Quality Parameters and Granulated Powder Properties: Feasibility Study Particulate Science and Technology – Volume 30, Issue 5, 2012

Development of a multiple-unit tablet containing enteric-coated pellets Pharmaceutical Development and Technology – April 2011, Vol. 16, No. 2 , Pages 118-126

Rate-dependent mechanical properties of dry blended pharmaceutical powder formulations for tabletting applications Powder Technology – Volume 207, Issues 1–3, 15 February 2011, Pages 26–34

Application of cross-linked rice starches as drug delivery matrices in monolithic tablets Discovery – University of Arkansas Dale Bumpers College of Agricultural, Food and Life Sciences – Vol 10, Fall 2009

Dry powder composition comprising a benzodiazepine for pulmonary inhalation Patent Application #US 20070081948 A1, Wiltshire, United Kingdom

Feasibility of Relationships between Tablet Physical Quality Parameters and Mechanical Properties of Dry Powder Formulation KONA Powder and Particle Journal No.30 (2013) - Pandeya and Puri - The Pennsylvania State University (2012-05-04)

(…) Bioavailability of 40mg sublingual epinephrine tablet formulationsRelationship between mechanical properties of pharmaceutical powder formulations and tablet quality parameters Publication for 6th International Conference for Conveying and Handling of Particulate Solids: 3-7 August 2009

Fast-disintegrating Sublingual Tablets: Effect of Epinephrine Load on Tablet Characteristics" AAPS PharmSciTech 2006; 7 (2) Article 41 - Rawas-Qalaji et Al, Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada (2006-03-14)

Phosphorylation of Starch Via Reactive Extrusion for Sustained Release of Drugs Dissertation by Stephen John O'Brien, University of Michigan, Ann Arbor MI, USA

Deformation properties of pharmaceutical excipients determined using an in-die and out-die method International Journal of Pharmaceutics – Volume 446, Issues 1–2, 25 March 2013, Pages 6–15

Sustained release properties of cross-linked corn starches with varying amylose contents in monolithic tablets Starch – Volume 62, Issue 3-4, pages 165–172, April 2010

Equipment List - University of Gent, Belgium, Dept. Of PharmaceuticsFlow Properties of Selected Pharmaceutical Powders Master Thesis by Erica Emery, Department of Chemical Engineering, University of Saskatchewan, Saskatoon, Canada

Multilayer tablet Patent Application #US 20070190144 A1, Intelgenx Corp, Ville St-Laurent (Quebec), Canada (2006)

Composition, device, and method for treating sexual dysfunction via inhalation Patent Application #US US20100018523 A1, John Nicolas Staniforth et al. (2009)

CBushu Pharmaceuticals Ltd – Manufacturing Equipment List