CIP Systems

CIP Systems

Clean, safe and time saving. We have optimised the cleaning processes and matched the factors perfectly to one another. Regardless of whether it is piped and fully automated for big plants or mobile and flexible for smaller bioreactors, you will be pleased with a clean solution.


  • Mechanical components (static or rotating spray balls, CIP lances), chemical substances (NaOH, acids), temperature of the cleaning agents, reaction and rinsing durations, all play a role in the cleaning process. Optimizing each individual component involved leads to a short, economic and ecologic CIP process.
  • Merely cleaning the vessel is not enough: Piping connected to the vessel, components, dosing and harvesting lines, are as much part of the CIP process, as are mixing tanks and dosage vessels. In production plants, CIP loops are precisely defined in order to ensure that all transitional zones are sufficiently cleaned and rinsed.
  • A PLC is programmed for the cleaning, in order to automate the CIP process. This is where the cleaning process and the cleanliness of the system are documented, and – if necessary – certain steps are adapted, in which contrary to expectation, the cleaning was incomplete.
  • Typical CIP steps (special processes may require other steps or cleaning agents):
    Pre-rinsing (PW)
    Cleaning with alkaline solution (2-3 % NaOH)
    Rinsing (PW)
    Final rinsing (WFI)
    Blowing out
  • The goal of successful cleaning is that all surfaces in contact with the product are left free of contamination and cell debris, so that cross-contamination between batches is avoided.


  • Safe and reproducible cleaning
  • Comprehensive concepts for all components to be cleaned
  • Recyclability

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  • Bioengineering's most simple CIP system is the CIP-mobile with up to 28 programmable cleaning steps, two 200 liter tanks, circulation pump, heat exchangers for steam, measurement and control of critical parameters (temperature, flow rates, conductivity) and recyclability of the cleaning solutions.
  • Rigidly installed CIP systems for plants are always designed and built to process requirements. They may consist of a tank, in which water is stored and solutions are mixed, or of several vessels for various cleaning solutions and rinsing water.
  • To avoid cross-contamination, rinsing liquids are internally recirculated to the receiver, and not fed back to the CIP tank. When cross-contamination is not an issue, CIP solutions are recycled to a high degree within the CIP system.
  • The documentation and automation level can be freely chosen in order to correspond with applicable regulations.



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